Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans
Summary: Metabolic routing of nicotinamide (NAM) to NAD+ or 1-methylnicotinamide (MeNAM) has impacts on human health and aging.NAM is imported by cells or liberated from NAD+.The fate of 2H4-NAM in cultured cells, mice, and humans was Decorative Plaques determined by stable isotope tracing.2H4-NAM is an NAD+ precursor via the salvage pathway in cul